The NYCOMPS consortium aims to accelerate the acquisition of structural information about membrane proteins by applying a structural genomics approach informed by the collective experience of a team of expert investigators. We have established the New York Consortium on Membrane Protein Structure (NYCOMPS) to work together toward this objective. Our pipeline for structure determination selects targets through a bioinformatics analysis of all known sequences, moves on to recombinant cloning, protein expression and protein purification at moderately high throughput, and then completes structures by x-ray crystallography. Our Protein Production Facility at the New York Structural Biology Center (NYSBC) handles targets through purification at a mid-scale level; and successful candidates are distributed to participant laboratories for scale-up and crystallization. Functional analysis of structures is performed both by computations and through routine experimental biochemistry. Targets are identified through nominations from the biological community and from NYCOMPS biological themes. Our biological themes include the overarching aspiration to explore the complete space of sequence-structure relationships for membrane proteins, with a particular focus on human proteins, and a second theme concerns membrane proteins associated with diabetes and related metabolic disorders.
Become a NYCOMPS adjunct member!
Structural biology princliple investigators in the North East can apply to become a NYCOMPS adjunct member. You can choose to have your protein of interest passed through the NYCOMPS pipeline. The PSI policies and mechanism to do this are listed here. Or take verified membrane proteins expressing clones to work up in your own lab. Contact us for details!
The 2013 NYCOMPS annual meeting will be held in November at NYSBC.